Eur Rev Med Pharmacol Sci 2007; 11 (1): 59-64

Apoptosis induction by quinazoline-derived alpha1-blockers in prostate cancer cells: biomolecular implications and clinical relevance

C. Alberti

Surgical Semeiotics, University of Parma (Italy)

Abstract. – In patients with androgen-sensitive prostate cancer androgen-deprivation therapy leads to apoptosis of hormone-dependent cells but it may select out androgen-refractory clones. The apoptosis of prostate cancer cells induced by quinazoline-derived alpha1-adrenoceptor antagonists (doxazosin, terazosin, prazosin) counteracts cell proliferation and may have the potential of reversing or delaying prostate cancer growth. Elucidation of the biomolecular mechanisms whereby quinazoline-alpha1-adrenoceptor-antagonists are able to induce anoikis and apoptosis in androgen-refractory prostate cancer cells would be favorable for designing effective therapeutic regimens in the management of advanced prostate cancer.

Corresponding Author: Contardo Alberti, MD; cell: +39.335.69.48.342

To cite this article

C. Alberti
Apoptosis induction by quinazoline-derived alpha1-blockers in prostate cancer cells: biomolecular implications and clinical relevance

Eur Rev Med Pharmacol Sci
Year: 2007
Vol. 11 - N. 1
Pages: 59-64

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