Investigation of the effect of the curcumin component as an alternative to the local treatment of nasal diseases

E. Ceylan, D. Turgut Cosan, N. Bayar Muluk, C. Cingi

Ceylan Private ENT Clinic, Isparta, Turkey. nbayarmuluk@yahoo.com

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• Otorhinolaryngology

OBJECTIVE: This study aimed to define the impacts of curcumin on nasal cell viability and proliferation.

MATERIALS AND METHODS: Specimens of healthy primary nasal epithelium were collected and incubated in cell culture during septorhinoplasty from people who signed a consent form. After implementing 2.5 µM curcumin in cultured cells, cell viability was defined via trypan blue assay, and proliferation was defined via the XTT method. The number of total cells, viability, and proliferation was defined. XTT (2,3-bis-(2-methoxy-4-nitro-5-sulphophenyl)-2H-tetrazolium-5-carboxanilide) experiments can be used to evaluate cellular toxicity.

RESULTS: The results revealed no harm to nasal cells after the topical implementation of curcumin. There was no significant change in the proliferation of the cells related to 24 hours of implementation. There was no adverse effect of using curcumin on the cell viability, either.

CONCLUSIONS: No cytotoxic effect on nasal cells has been observed after applying topically implemented curcumin. Curcumin could be used topically for an alternative treatment for allergic rhinitis as it has anti-inflammatory and immune response modulatory effects if clinical trials will confirm experimental data.

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