Evaluation of sleep disorders before and after transplantation in patients undergoing hematopoietic stem cell transplantation

F. Yavlal, Y.G. Aras, S.B. Ulaş

Department of Neurology, Medicana International Istanbul Hospital, Istanbul, Turkey. figenyavlal@hotmail.com

---

• Hematology
• Neurology
• Oncology

OBJECTIVE: Hematopoietic stem cell transplantation (HSCT) is an important curative treatment option for many hematologic diseases. Sleep disorders in patients with HSCT are a significant but often overlooked health problem. Therefore, this study aims to determine the frequency of sleep disorders in HSCT patients and to compare and evaluate the data before and after transplantation between autologous and allogeneic HSCT patient groups.

PATIENTS AND METHODS: Patients who were referred to the Bone Marrow Transplantation Centre Clinic at Medicana International Istanbul Hospital by other centres and those who were suitable for HSCT treatment according to evaluations were included in the study. The patients underwent allogeneic and autologous HSCT. The Pittsburgh Sleep Quality Index (PSQI), Epworth Sleepiness Scale (ESS) and Insomnia Severity Index (ISI) were applied to both groups before transplantation and on the 7th and 100th days after transplantation.

RESULTS: The PSQI total and sub-scale scores, ESS scores and ISI scores on the 7th and 100th days after transplantation were statistically significantly lower than the scores before transplantation.

CONCLUSIONS: Sleep disorders were significantly reduced in patients after HSCT. Moreover, the scores in the seven subscales of the PSQI statistically significantly decreased on the 7th and 100th days after transplantation, and sleep statistically improved and showed great improvement on the 100th day after transplantation. We believe that early detection and treatment of sleep disorders may be beneficial for this group of patients to improve their quality of life and response to treatment.

Free PDF Download