Liver radiologic findings of chemotherapy-induced toxicity in liver colorectal metastases patients

V. Granata, R. Fusco, S. Venanzio Setola, M. Mattace Raso, A. Avallone, A. De Stefano, G. Nasti, R. Palaia, P. Delrio, A. Petrillo, F. Izzo

Division of Radiology, Division of Abdominal Oncology, Division of Hepatobiliary Surgical Oncology; “Istituto Nazionale Tumori – IRCCS, Fondazione G. Pascale”, Naples, Italy. r.fusco@istitutotumori.na.it

---

• Radiology

There are a number of chemotherapy-effects that should be assessed with liver imaging since they have an influence on surgical morbidity. Chemotherapy-related complications, steatosis, chemotherapy-associated steatohepatitis (CASH), and SOS might impair the hepatic parenchyma, thus reducing the functionality and influencing the outcome following resection. The main role of a radiologist is to provide an accurate diagnosis of the lesion. With constant advances in medicine, a radiologist’s role should extend beyond just reporting the data of tumor, providing additional information that may greatly improve patient care. Radiologists should assess both chemotherapy effects on the hepatic metastasis itself, as well as chemo-induced focal and diffuse modifications of non-tumor hepatic parenchyma, since it is important to avoid impaired hepatic function after hepatic resection.

Free PDF Download