HLA-DPA1 gene polymorphism in primary glaucoma

J.-H. Li, J.-F. Shao, Z.-G. Sui, Y.-X. Qin

Department of Laboratory Medicine, Affiliated Hospital of Weifang Medical University, Weifang, China. yiwugongzuo@126.com

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• Geriatrics

OBJECTIVE: To explore the association between human leukocyte antigen (HLA)-DPA1 gene polymorphism and primary glaucoma.

PATIENTS AND METHODS: Six single nucleotide polymorphisms (SNPs) were genotyped in 51 patients and 51 healthy controls through Polymerase Chain Reaction (PCR). The possible association between HLA-DPA1 gene mutation and primary glaucoma was detected using the t-test and the Chi-square test.

RESULTS: Rs1676486 genotype had a significant genetic correlation. Rs3753841 and rs12138977 genotypes had a higher minor-allele frequency in control group. The CT + CC genotype frequency of rs12138977 showed a significant genetic correlation in both case group and control group. Moreover, the rs12138977 polymorphism and corneal thickness had little influence on the occurrence of primary angle-closure glaucoma (PACG). Also, the main risk factors for PACG were intraocular hypertension and short axial length.

CONCLUSIONS: The HLA-DPA1 gene polymorphism may be related to the severity of PACG.

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