Persistent eradication of Helicobacter pylori after systemic politherapy associated with periodontal pockets treatment with metronidazole and calcium sulphate

A. Tarullo, M. Tattoli*, R. Cagiano*

* Department of Pharmacology
Human Physiology, Pharmacology Section, Medical School
University of Bari (Italy)

---

• Gastroenterology

Abstract. – The sensitivity of H. Pylori to antibiotic treatment is well known. Politherapy (omeprazole or pantoprazole or ranitidine, amoxicillin and/or azithromycin and/or clarithromycin, metronidazole and bismuth citrate) notably changed the percentage of H. pylori eradication but rarely resolutive. Periodontal pockets treatment with topic metronidazole, calcium sulphate and potassium sulphate resulted active against bacteria included in periodontal pockets leading to a long-term H. pylori eradication (two years follow-up).