Effects of new probiotic mouthwash in patients with diabetes mellitus and cardiovascular diseases

P. Bollero, L. Di Renzo, R. Franco, T. Rampello, A. Pujia, G. Merra, A. De Lorenzo, R. Docimo

Department of Systems Medicine, Medical School, University of Rome “Tor Vergata”, Rome, Italy. delorenzo@uniroma2.it

---

• Pharmacology

OBJECTIVE: To evaluate the impact of a new formulation of probiotic mouthwash (PM), using Biocult strong® dissolved in neutral mouthwash.

PATIENTS AND METHODS: Forty-two patients with cardiovascular disease (CVD) or type 1 and type 2 diabetes were enrolled. Plaque Control Record (PCR) and Bleeding on Probing (BOP) were assessed at baseline and after two weeks of PM or positive control treatment in intervention group (IG) and control group (CG). Food intake was estimated by 3-day diet record.

RESULTS: BOP was significantly reduced in all treatments and samples, except for IG in CVD sample (p=0.15). PCR decreased significantly in all treatments and samples (p<0.01). No significance was obtained for BOP and IP in the time x group interaction. Food intake was not significantly different between IG and CG in all samples. Nutrients such as fats and simple carbohydrates were correlated with BOP in patients who received positive control, rather than PM, indicating a lack of food influence on BOP and PCR in IG.

CONCLUSIONS: PM treatment was effective in relation to the reduction of PCR and BOP. Probiotics represent a good, but additional, tool for prophylaxis, because they cannot completely substitute the classic oral hygiene methods. Moreover, one week of treatment was not sufficient to draw firm conclusions about the efficacy of the treatment itself.

Free PDF Download