Effect of serum high molecular weight adiponectin level on the occurrence of eclampsia during subsequent pregnancy in patients with primary pregnancy induced hypertension

Y. Zhou, Z.-H. Chen, X.-L. Zhao, Y.-H. Qiao, R.-X. Guo

Department of Obstetrics, First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, PR China. za6e30@163.com

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• Obstetrics

OBJECTIVE: To analyze the effect of serum levels of high molecular weight adiponectin (HMWA) on the occurrence of eclampsia during subsequent pregnancy in patients with primary pregnancy-induced hypertension (PIH).

PATIENTS AND METHODS: Thirty patients with primary PIH (observation group) and sixty patients without primary PIH (control group) were consecutively selected. ELISA was used to measure the serum levels of HMWA. The differences in the occurrence of eclampsia during subsequent pregnancy between the two groups were compared.

RESULTS: The serum levels of HMWA in the observation group were significantly lower than in the control group, and they decreased with increased severity of PIH (p < 0.05). In the observation group, the gestational age was lower than that of the control group, and the occurrence of cesarean section and maternal complications were increased. The neonatal weight and Apgar scores were lower than those of the control group, and the occurrence of neonatal complications was increased. The difference was statistically significant (p < 0.05). There were no differences in the time intervals between pregnancies in the two groups. The occurrence of PIH and eclampsia during subsequent pregnancy in the observation group was significantly higher than that in the control group (p < 0.05). According to receiver operating curve analysis, the sensitivity, specificity, and accuracy of serum HMWA level in predicting the occurrence of eclampsia during subsequent pregnancy were 85.6%, 74.8%, and 0.824 (95% CI = 0.811-0.936, p = 0.015), respectively. The critical value was 2.4 mg/l.

CONCLUSIONS: Decreases of serum levels of HMWA in patients with primary PIH are closely related to the severity of PIH and the outcome of pregnancy, which has important predictive value for the occurrence of eclampsia during subsequent pregnancy.

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