Chronic constipation in hypercalcemic patients with primary hyperparathyroidism

A. Ragno, J. Pepe*, D. Badiali**, S. Minisola*, E. Romagnoli*, C. Severi**, E. D’Erasmo*

Unit of Internal Medicine, Nuovo Regina Apostolorum Hospital, Albano Laziale, Italy

*Department of Internal Medicine and Medical Disciplines, “Sapienza” University, Rome, Italy

**Chair of Gastroenterology, Department of Internal Medicine and Medical Disciplines, “Sapienza” University, Rome, Italy

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• Gastroenterology

BACKGROUND: Chronic constipation (C), among gastrointestinal symptoms, is commonly associated with primary hyperparathyroidism (PHPT) and probably attributable to hypercalcemia.

OBJECTIVE OF THE STUDY: To evaluate in patients affected with PHPT the prevalence of C utilizing a validated questionnaire and the current prevalence of C compared to that observed in the past and to evaluate the relationship between C and the severity of PHPT.

METHODS: 55 outpatients affected with PHPT, admitted to our Department of Internal Medicine and Medical Specialities in the years (2006-2009) were studied (group 1: 50 postmenopausal women and 5 men, mean age 61.9 ± 9.4 years), together with 55 sex and age matched controls (group 2). Also considered were a group of PHPT patients observed, in the same ambulatory, during the years ’70-’80 (group 3). A questionnaire, Rome II criteria, was administered and used to define C, whereas only anamneses were used to define C in group 3.

RESULTS: The prevalence of C in patients with PHPT was 21.8% in group 1 vs 12.7% in group 2 (n.s.) and 32.7% in group 3. There is a decreasing trend in the prevalence of C in patients with PHPT as observed from 1970-89 to 2006-2009 (p < 0.05). The reduction of C was associated together with a significant reduction in the serum calcium level (p < 0.001). The presence of C vs its absence in patients with PHPT is characterized by higher values of calcemia (p < 0.001), ionized calcium (p < 0.001), and parathyroid hormone (p = 0.019).

CONCLUSIONS: The actual prevalence of C in patients with PHPT is not significantly different from that found in the control group and is decreasing with respect to the past years. Moreover, C seems to be associated with the severity of the disease rather than with the diagnosis of PHPT per se.

Corresponding Author: Jessica Pepe, MD; e-mail: jesspepe@tin.it